Research and Case Studies
Molecular hydrogen is being heavily researched since 2007.
The earliest written record of the therapeutic effects of hydrogen dates back to around 1793, when Beddoes, Cavallo, and Davy published papers on the effects of gases on human respiration.
However, hydrogen was largely considered biologically inert until 2007, when Ohsawa et al. published a paper in Nature Medicine that sparked a new wave of interest in hydrogen's medical uses. Since then, over 2000 scientific papers have been submitted and hundreds of clinical trials have been conducted in a wide spectrum of applications. Some of the applications researched are:
- Anti-inflammatory: Hydrogen can reduce inflammation and improve blood pressure.
- Anti-oxidative: Hydrogen can reduce oxidative stress in the body and protect cells from damage.
- Sterilization: Hydrogen gas can kill microorganisms and sterilize equipment without leaving toxic byproducts or residue.
- Lung injury: Hydrogen can reduce lung injury caused by ventilators.
- Rheumatoid arthritis: Hydrogen-rich water can improve the inflammatory cytokine expression of rheumatoid joints.
- Many others...
Hydrogen can be administered in a variety of ways, including breathing it, drinking a hydrogen-rich solution, administering it as saline or soaking in bath enriched with hydrogen.
For more unbiased scientific information, we encourage you to check in with the Molecular Hydrogen Institute, a non-profit organization dedicated to the fellowship, research and education of this area.
Hydrogen gas as a treatment for Ischemia in ECPR events
PROF. JOHN KHEIR, MD.
Associate Professor of Pediatrics, Harvard Medical School Staff Physician, Boston Children’s Hospital
John Kheir, MD is a distinguished cardiac intensive care physician at Boston Children’s Hospital. Since joining the Heart Center in 2010, he has dedicated himself to caring for critically ill children with congenital heartdisease. Dr. Kheir is an Associate Professor of Pediatrics at Harvard Medical School. His Translational ResearchLab has been continuously federally funded for more than 16 years to develop innovative diagnostics andtreatments for oxygen deprivation, including the development of injectable oxygen to reduce patients from profound hypoxemia and the translation of hydrogen gas from animal to FDA-regulated human trials. His dual commitment to clinical excellence and research innovation drives his mission to bring life-saving technologies to market.
Overview of hydrogen medicine from the initiation to future mission
PROF. SHIGEO OHTA, PHD.
Professor, Department of Neurology Medicine, Graduate School of Medicine; Institute for Advanced Sciences, Nippon Medical University; H2Global Group
Dr. Shigeo Ohta is currently a Professor Emeritus at Nippon Medical University, Tokyo, Japan and a Visiting Professor of Juntendo University, Tokyo, Japan. He graduated from the university of Tokyo in 1974, and received his phD from the university of Tokyo in 1979. He is serving as the Honorary President of the Japanese Society of Mitochondrial Research and Medicine, the Japanese Biomedical Society for Molecular Biology and International Society for Hydrogen Medicine and Biology. His total publication citations are 17,400 and his h-index is 70. In the hydrogen medicine, he discovered the biomedical function of molecular hydrogen and published a historical article in Nature Medicine 2007 and is known as the pioneer of hydrogen medicine. This article has been cited 2,700 and 1,900 times by Google Scholar and Scopus, respectively. In addition, he is serving as the director of hydrogen companies including H2 Global Group, Ostrava, Czech Republic.
New concept of using hydrogen for health (in Chinese with English Slides)
PROF. XUEJUN SUN, PHD.
Retired Professor, Second Military Medical University of China; Honorary Chairman, Shanghai Huikang Hydrogen Medical Research Center
Prof. Xuejun Sun is a retired professor from the Second Military Medical University of China and currently serves as the honorary chairman of the Shanghai Huikang Hydrogen Medical Research Center. Since 2007, he has been committed to the research and popularization of the biomedical effects of hydrogen, and has published more than 100 peer-reviewed papers on the medical effects of hydrogen, edited and published fourbooks on hydrogen medicine, written thousands of popular science articles on hydrogen medicine, participated in the establishment of several hydrogen medicine academic organizations, and played an important role in promoting the academic research and application of hydrogen medicine in China and even internationally. In 2022, he was selected as an “distinguished leadership in molecular hydrogen research” by the European Academy for Molecular Hydrogen Research in Biomedicine.
Hydrogen inhalation therapy for post-cardiac arrest syndrome: a novel and promising approach
PROF. MASARU SUZUKI, MD, PHD.
Professor and Director of Department of Emergency Medicine, Tokyo Dental College Ichikawa General Hospital; Special Appointment Professor of The Center for Molecular Hydrogen Medicine, Keio University
Prof Masaru Suzuki received his MD degree from Keio University in 1992. He trained in emergency medicine and internal medicine. He received his PhD in 2007. Since 2017, he has been Professor and Director of the
Department of Emergency Medicine at Tokyo Dental College Ichikawa General Hospital. His research interests include sudden cardiac arrest and resuscitation science. In particular, he was the Principal Investigator (PI) of the HYBRID trial, a clinical trial investigating the use of hydrogen inhalation therapy for post cardiac arrest syndrome. This trial attracted significant attention as it introduced a novel approach to improving recovery in patients following cardiac arrest, and marked a significant advance in the field under his leadership.
Hydrogen inhalation for improving health and quality of life in the elderly
ASST. PROF DARINKA KOROVLJEV, PHD.
Applied Bioenergetics Lab,
Faculty of Sport and Physical Education,
University of Novi Sad, Novi Sad
Asst. Prof Darinka Korovljev, born in 1976, has scientific experience from working on implementing differenthealth interventions in the aging population. She holds a Ph.D. in molecular hydrogen research from the University of Novi Sad and has a postdoctoral fellowship in the Applied Bioenergetics Lab. Dr. Darinka Korovljev manages the lab’s international projects, and she is a member of several international research teams seeking to create new pilot programs and potential curricula to improve future teaching content and educationalprograms in public health and healthy lifestyles in different populations. She is an assistant professor at the Faculty of Sport and Physical Education, University of Novi Sad, within the Research Methods in PhysicalActivity, Fitness, and Wellness subject group.
Molecular hydrogen as a useful gas for slow-aging
PROF. MAMI NODA, PHD.
Chikushi Clinic; Institute of Mitochondrial Biology and Medicine of Xi’an Jiaotong University School of Life Science and Technology; RUDN University
Dr. Mami Noda is a pathophysiologist and pharmacologist. After being postdoctoral fellow at the Rockefeller University, she has been conducting brain science in a Laboratory of Pathophysiology in the Graduate School of Pharmaceutical Sciences at Kyushu University. After retiring the Kyushu University, she has been involved inteaching and helping research in several universities. She is now also in a obsterics and gynecology clinic, helping women’s health.
Molecular hydrogen as a potential modulator of brain metabolism
PROF. SERGEJ M. OSTOJIC, MD, PHD
Professor of Nutrition, University of Agder, Professor of Biomedical Sciences, University of Novi Sad; Professor of Health Sciences, Universityof Pécs
Dr. Sergej M. Ostojic earned his MD from the University of Belgrade in 1996 and a PhD in Medical Sciences in 2003. He completed further training at Mayo Clinic and Harvard. Currently, he is a Professor of Nutrition at the University of Agder, Biomedical Sciences at the University of Novi Sad, and Health Sciences at the University of Pécs. His research focuses on mitochondrial health and nutritional interventions for chronic diseases. Dr. Ostojic has published over 320 peer-reviewed articles, authored 13 book chapters, and holds 11 patents. He is an Associate Editor for Clinical Nutrition ESPEN and Research in Sports Medicine, among others. He has received numerous prestigious research grants and is active in international research networks such as the WHO’s European Childhood Obesity Surveillance Initiative and the Global Burden of Disease project.
Hydrogen intake relieves alcohol consumption and hangover symptoms in healthy individuals; a randomized and placebo-controlled crossover study
PROF. GUOHUA SONG, PHD.
Shandong First Medical University & Shandong Academy of Medical
Sciences
Song Guohua, is a Young Taishan Scholars Scientist of Shandong Province, professor at Shandong First Medical University, supervisor for Ph.D postgraduates, Deputy Director in School of Basic Medical Sciences, Shandong First Medical University. Dr. Song Guohua received her Ph.D of Medical Science from Yonsei University, South Korea. Her research focuses on lipid and lipoprotein metabolism and the application of molecular hydrogen, an emerging anti-oxidative gas. Her work has been supported by the National Science Foundation of China for 4 times, and also by the Science Foundation of Shandong Province for 2 times. She has published more than 40 SCI papers, including Arteriosclerosis, Thrombosis, and Vascular Biology, The American Journal of Clinical Nutrition, J Clin Endocrinol Metab, Free Radi Bio Med, J Lipid Res, BBA-MOL CELL BIOL L, and Atherosclerosis. Besides, she was appointed as member of the Standing Committee of the Molecular Hydrogen Biomedicine, members of the Young Scholar Committee of Biochemical and Molecular Pharmacology, members of the Specialist Expert Committee of Molecular Hydrogen Biomedical Special fund for development. In addition, she was awarded "Science & Technology Award for Young Talents" by Shandong Province and she is one of the main candidate to receive the Award of the science and technology progress in Shandong Province. In recent years, she was invited to attend the Academic conferences at home and abroad and provide the oral presentations as the invited speaker.
Hydrogen-rich water as the new therapy for neuropathic pain and the emotional disorders associated
DR. OLGA POL, PHD.
Molecular Neuropharmacology Group, Sant Pau Research Institute and Autonomous University of Barcelona
Dr. Olga Pol is coordinator of the Molecular Neuropharmacology Group at the Sant Pau Research Institute and at the Neurosciences Institute of the Autonomous University of Barcelona, Spain. She is editor of the journal Antioxidants and a member board director of the European Academy for Molecular Hydrogen Research in Biomedicine. Her research focuses on the investigation of new strategies for the treatment of chronic pain and the emotional/cognitive disorders associated, and in the search of novel approaches to improve the antinociceptive actions of conventional analgesics. Her investigations reveal the analgesic, anxiolytic and/or anti-depressant properties of molecular hydrogen, carbon monoxide and hydrogen sulfide in different pre-clinical models of chronic pain as well as their capacity to improve the analgesic effects of opioids and cannabinoids during chronic pain.
Hydrogen-rich water as an adjunct treatment for sports injuries
DEJAN JAVORAC, MSC.
Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad
Dejan Javorac, born in 1987, is a PhD student, lab technician, and teaching assistant at the Faculty of Sports and Physical Education, University of Novi Sad. He designs and tests innovative therapeutics that protect and improve mitochondrial bioenergetics and metabolism in healthy and diseased individuals. His research is broad, covering a range of pathologies, including athletic performance, traumatic brain injury, and neurodegenerative diseases. He explores the value of inhalational, topical, and oral hydrogen in these areas, aiming to significantly impact each field.
The role of mast cells in remodelling effects of molecular hydrogen on the lung local tissue microenvironment
DR. DMITRII ATIAKSHIN, MD.
Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies RUDN University
Advisor to the Rector of RUDN University, Director of the Scientific and Educational Resource Center "Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis
(Molecular Morphology)" RUDN University, Doctor of Medical Sciences, Associate Professor
Professional skills: molecular histology, histochemistry, monoplex and multiplex immunohistochemistry, spatial phenotyping of tissue microenvironment, spatial proteomics and interactomics, cytology, transmission immunoelectron microscopy, bioinformational analysis.
Areas of scientific interest: functional morphology of the tissue microenvironment during adaptation and pathology (inflammation, oncogenesis, fibrosis); spatial profiling of the immune and stromal landscape; biology of mast cells, remodeling of connective tissue, fibrillogenesis of collagen; intercellular signaling, space biomedicine, hydrogen biomedicine, regenerative medicine.
The beneficial effects of hydrogen-rich saline irrigation on allergic rhinitis
PROF. DR. SHAOQING YU, PHD.
Department of Otolaryngology, Tongji Hospital, School of Medicine
Prof Dr Yu is the Director of the Department of Otolaryngology Head and Neck Surgery and Allergy at Tongji Hospital. He is a member of the European Society for Allergy and Immunology (EAACI), a member of the Chinese Association of Traditional Chinese and Western Medicine Otolaryngology Sciences. He has undertaken more than 20 research projects, including the National Natural Science Foundation of China. Published over 60 papers in renowned top journals in allergy immunology, such as Allergy and Clin Rev Allergy Immuno. Long term commitment to basic and clinical research on allergic rhinitis: systematically conducted research on the regulation of medical gas signals in allergic rhinitis, proposed the use of exhaled NO and CO levels for auxiliary diagnosis of AR, and invented a new treatment method of nasal lavage with hydrogen rich saline; Established the Shanghai Municipal Health Commission’s Center for the Promotion, Application, and Standardized Management of allergen Specific Immunotherapy for Allergic Rhinitis, and carried out immunotherapy using stem cells and exosomes for allergic rhinitis; Led the completion of three expert consensus/guidelines for surgical treatment of allergic rhinitis, and participated in the 15 expert consensus/guidelines. He has won the third prize of Shanghai Medical Technology Award, the third prize of Military Medical Achievements Award, Tongji University Taihe Medical Education Award, and more than 20 personal patents, and have been selected for the Shanghai Oriental Talent Program.
Cancer and Molecular Hydrogen
Scientific References
- Nakashima-Kamimura et al., 2009 (Cancer Chemotherapy and Pharmacology) Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.
- Hirano et al., 2024 (Biomedicines) Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation.
- Zhou et al., 2024 (Journal of Cancer Research and Clinical Oncology) Prospects of molecular hydrogen in cancer prevention and treatment.
- Tian et al., 2021 (Frontiers in Physiology) Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis.
- Rahman et al., 2023 (Antioxidants) Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity.
- Murakami et al., 2017 (PloS One) Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis.
- Hirano et al., 2021 (International Journal of Molecular Sciences) Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression.